Tuesday, August 29, 2006

Numbers In and Up!

We made our regular trip to Sick Kid's this morning so that Parker may receive his PEG-ADA injection. We normally go a little earlier so that Parker may give some blood so that a CBC (complete blood count) can be done on him, but that was not going to be the case today. We were told last week that he was not going to have to give blood every week, and that every other week would suffice. This was because he seemed to be doing so well, and the weekly blood work always seemed to be yielding the same results.

Last week, Parker gave enough blood so that another T and B-cell marker could test could be done using flow cytometry. The last time that this test was performed was on June 6th and informed us that his thymus gland was still not functioning appropriately yet. The marker test gives us an absolute count of the different lymphocytes Parker has. Recall that there are three different types of T-cells that are matured in the thymus gland. For the first time ever, we finally had some evidence that Parker has significant numbers of these types of cells. On June 6th Parker had 121 cells /uL of CD3+/CD4+ T-cells, today the test informed us that he now has 592 cells/uL. On June 6th, the test revealed that Parker had 13 cells/uL of CD3+/CD8+ T-cells
, today the test revealed he had 232 cells/uL. On average, his mature T-cells have increased from 168 cells/uL to 903 cells/uL.

To say that my wife and I were happy about the results is definately an understatement. Now, these numbers are still below what is considered normal for a child his age without an ADA deficiency but they are very good for a child with ADA deficiency.

Parker is currently receiving ADA enzyme replacement therapy to replace the missing enzyme that his body is incapable of producing. As a result, the enzyme has mopped up the toxins in his body that is causing his lymphocytes to be killed off. I had mentioned in numerous articles dating back to the time we had to decide on a treatment for Parker in April that long term enzyme replacement therapy is not a successful long term treatment for ADA Deficient Severe Combined Immunodeficiency and for that reason we disregarded it as his treatment. That said, he must remain on it for six months to take part in the gene therapy trial in Milan, Italy. The fact that he is capable of producing the different forms of T-cells lets me know that his thymus is capable of working. This is important because his thymus will need to do the same thing when it comes to gene therapy; it will have to mature T-cells.

Parker currently has an absolute count of 468 cells /uL of his natural killer(CD56+) cells and 1117 cells/uL for his B-cells (CD20+). His high number of B-cells means that there will not be any more IgG troubles for a long while.


nonna said...

Way to go Big Guy!

Yeah! You did it!
We are so glad that you are creating all these cells that your Dad is talking about, it can only mean that you are a very strong boy. We can hardly wait for you to start your Gene Therapy treatment.
Keep it up.
Stay strong Big Guy!

Love you tons.

Nonno & Nonna

Natalie said...

Hey Parker!

YIPPEE!!! I am so happy that all of your numbers are going up! What a trooper you are! Your Mommy sounded so happy on the phone today Parker Poo! We are all so excited for you!

Keep up all of your hard work little one.

Hugs and Kisses,
Auntie Natalie xoxo

Elizabeth said...

Yay yay yay!

I was thinking about you today because I knew you were at the hospital...I am so glad your numbers are up! That is awesome!!!

Keep on truckin' you cute little guy, you!


nana said...

We are so hapy that your numbers are up - although really was there any doubt that you would come through as you do with everything else.

You are our little man and we love you so very much.

Wait till they see you in Italy and see how determined you are and how successful the gene therapy will be.

All will be good.

Much love,
Nana and Granddad xoxo